Recreational Physical Activity and Outcomes After Breast Cancer in Women at High Familial Risk

RD Kehm; RJ MacInnis; EM John; Y Liao; AW Kurian; JM Genkinger; JA Knight; SV Colonna; WK Chung; R Milne; N Zeinomar; GS Dite; MC Southey; GG Giles; SA McLachlan; KD Whitaker; ML Friedlander; PC Weideman; G Glendon; S Nesci; KA Phillips; IL Andrulis; SS Buys; MB Daly; JL Hopper; MB Terry

Journal article

Recreational Physical Activity and Outcomes After Breast Cancer in Women at High Familial Risk

RD Kehm, RJ MacInnis, EM John, Y Liao, AW Kurian, JM Genkinger, JA Knight, SV Colonna, WK Chung, R Milne, N Zeinomar, GS Dite, MC Southey, GG Giles, SA McLachlan, KD Whitaker, ML Friedlander, PC Weideman, G Glendon, S Nesci Show all

Jnci Cancer Spectrum | OXFORD UNIV PRESS | Published : 2021

DOI: 10.1093/jncics/pkab090

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Abstract

Background: Recreational physical activity (RPA) is associated with improved survival after breast cancer (BC) in average-risk women, but evidence is limited for women who are at increased familial risk because of a BC family history or BRCA1 and BRCA2 pathogenic variants (BRCA1/2 PVs). Methods: We estimated associations of RPA (self-reported average hours per week within 3 years of BC diagnosis) with all-cause mortality and second BC events (recurrence or new primary) after first invasive BC in women in the Prospective Family Study Cohort (n = 4610, diagnosed 1993-2011, aged 22-79 years at diagnosis). We fitted Cox proportional hazards regression models adjusted for age at diagnosis, demogr..

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University of Melbourne Researchers

Robert MacInnis Author

Roger Milne Author

Gillian Dite Author

Melissa Southey Author

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Grants

Awarded by National Cancer Institute

Funding Acknowledgements

The 6 sites of the Breast Cancer Family Registry were supported by grant U01 CA164920 from the USA National Cancer Institute. This work was also supported by grants to kConFab and the kConFab Follow-Up Study from Cancer Australia (grant numbers 809195, 1100868), the Australian National Breast Cancer Foundation (grant number IF 17 kConFab), the National Health and Medical Research Council (grant numbers 454508, 288704, 145684), the National Institute of Health USA (grant number 1R01CA159868), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia (grant numbers not applicable). KAP is a National Health and Medical Research Council Leadership Fellow (grant number 1195294).